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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabla, Pancho | RP | Rizao Rally Cats | 27 | 05/17/2042 | Arraijan | PAN | Left | Left | 6' 1" | 200 lbs | $350,000 |
| Sagredo, Aurelio | CL | Colon Cougars | 24 | 04/17/2045 | Santiago | DOM | Right | Right | 6' 3" | 200 lbs | $350,000 |
| Sakai, Okitsugu | C | Colon Cougars | 25 | 10/31/2044 | Kyoto | JPN | Right | Right | 5' 10" | 205 lbs | $350,000 |
| Salermo, Emesto | RP | Mexico City Gila Monsters | 30 | 01/05/2040 | Maracaibo | VEN | Right | Right | 6' 3" | 200 lbs | $933,750 |
| Sánchez, Rafael | RP | Oaxaca Nueve Garras de Jaguar | 28 | 01/19/2042 | Nogales | MEX | Left | Left | 6' 1" | 205 lbs | $750,000 |
| Sarasa, Ricardo | RP | Mexico City Gila Monsters | 34 | 09/25/2035 | Mérida | VEN | Right | Right | 6' 1" | 200 lbs | $480,000 |
| Sato, Taroemon | RP | Monterrey Alacranes | 28 | 06/28/2041 | Nagaoka | JPN | Right | Right | 6' 1" | 200 lbs | $350,000 |
| Scandoval, Raúl | 1B | Hong Kong Golden Dragons | 31 | 12/21/2038 | Vicente Noble | DOM | Left | Left | 6' 2" | 215 lbs | $600,000 |
| Sedúlveda, Salvatore | SP | Mexico City Gila Monsters | 23 | 05/14/2046 | Santa Clara | CUB | Right | Right | 6' 5" | 205 lbs | - |
| Sepólveda, Ivori | RF | Mao Dadaistas | 24 | 06/16/2045 | Tocumen | PAN | Left | Left | 6' 4" | 200 lbs | $350,000 |
| Sepúlbeda, Enrique | RP | Oaxaca Nueve Garras de Jaguar | 30 | 03/31/2040 | Lagunas de Nisibzn | DOM | Switch | Right | 6' 4" | 205 lbs | $750,000 |
| Shan, Siu-chung | 1B | Colon Cougars | 27 | 11/03/2042 | Wuhan | CHN | Left | Left | 6' 4" | 200 lbs | $350,000 |
| Shiomi, Toshikuni | SP | Quebec Dragons | 30 | 12/09/2039 | Sapporo | JPN | Right | Right | 6' 4" | 200 lbs | $350,000 |
| Shiratori, Akihito | 1B | Hong Kong Golden Dragons | 28 | 10/26/2041 | Oita | JPN | Right | Left | 6' 4" | 200 lbs | - |
| Shiyouji, Suketsune | SP | Hong Kong Golden Dragons | 34 | 05/05/2035 | Fujiidera | JPN | Left | Right | 6' 0" | 205 lbs | $11,883,412 |
| Silva, Peter | C | Mexico City Gila Monsters | 27 | 02/14/2043 | Lezn | MEX | Right | Right | 6' 0" | 200 lbs | $350,000 |
| Sin, Min-yul | RF | Colon Cougars | 29 | 07/09/2040 | Asan | KOR | Left | Left | 6' 0" | 200 lbs | $16,948,781 |
| Solly, stigmata | RP | Rizao Rally Cats | 31 | 05/18/2038 | Saint Catharines-Niagara | CAN | Right | Right | 6' 1" | 200 lbs | $350,000 |
| Speers, Eric | SP | Colon Cougars | 26 | 02/09/2044 | San Juan | PUR | Right | Right | 6' 1" | 190 lbs | $730,000 |
| Spittal, Kynan | 2B | Quebec Dragons | 24 | 03/13/2046 | Oak Grove | USA | Right | Right | 6' 1" | 190 lbs | $350,000 |
| Stady, Wayne | RP | Quebec Dragons | 32 | 05/21/2037 | La Tuque | CAN | Right | Right | 6' 1" | 195 lbs | $700,000 |
| Stanley, Wally | CL | Monterrey Alacranes | 35 | 11/29/2034 | Owatonna | USA | Right | Right | 6' 0" | 200 lbs | $1,600,000 |
| Stauffer, Matt | RP | Oaxaca Nueve Garras de Jaguar | 26 | 07/02/2043 | Peoria | USA | Left | Left | 6' 3" | 190 lbs | $350,000 |
| Sutton, Paul | C | Free Agent | 28 | 06/17/2041 | Barrie | CAN | Left | Right | 6' 4" | 200 lbs | - |
