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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saito, Noritoshi | RF | Villa Carmen Surveyors | 27 | 10/18/2042 | Togane | JPN | Left | Left | 6' 2" | 200 lbs | - |
| Sakiyurai, Kuniyuki | SS | Shaoguan Weevils | 26 | 11/13/2043 | Tokyo | JPN | Right | Right | 6' 1" | 200 lbs | - |
| Sang, Jing-bo | RP | Shaoguan Weevils | 26 | 08/25/2043 | Jinan | CHN | Right | Right | 6' 0" | 200 lbs | - |
| Santos, Madesio | C | Santa Fe Crusaders | 22 | 06/15/2047 | Cruces | CUB | Left | Right | 6' 0" | 195 lbs | - |
| Sasaki, Masahiro | 1B | Sosan Flame | 27 | 07/20/2042 | Kawaguchi | JPN | Left | Left | 6' 2" | 200 lbs | - |
| Sasaki, Oniji | CF | Sosan Flame | 28 | 10/24/2041 | Toyohashi | JPN | Right | Right | 6' 3" | 200 lbs | - |
| Sayago, René | SP | Shaoguan Weevils | 26 | 06/24/2043 | David | PAN | Left | Left | 6' 4" | 200 lbs | - |
| Scott, Rodolfo | LF | Loiza Racers | 27 | 11/30/2042 | Mexico City | MEX | Left | Left | 6' 0" | 200 lbs | - |
| Searle, Joe | 1B | Shaoguan Weevils | 26 | 09/14/2043 | Courtenay | CAN | Switch | Right | 6' 2" | 220 lbs | - |
| Sellers, Brandon | LF | Loiza Racers | 31 | 06/12/2038 | Guaynabo | PUR | Right | Right | 6' 3" | 205 lbs | - |
| Shearing, Aaron | C | Free Agent | 35 | 06/29/2034 | Edmonton | CAN | Right | Right | 6' 0" | 200 lbs | - |
| Shiu, Zi-xing | CF | Sosan Flame | 26 | 06/28/2043 | Yingshang | CHN | Right | Right | 5' 10" | 180 lbs | - |
| Silva, Guadalupe | RF | Loiza Racers | 25 | 11/23/2044 | Mexico City | MEX | Left | Left | 6' 0" | 195 lbs | - |
| Simoniello, Bartoli | C | Shaoguan Weevils | 26 | 12/29/2043 | San Juan de los Morros | VEN | Right | Right | 6' 0" | 205 lbs | - |
| Sobenes, Fanuco | C | Free Agent | 34 | 10/06/2035 | Candelaria | PUR | Right | Right | 6' 0" | 200 lbs | - |
| Soma, Senichi | SP | Cabano Black Aces | 32 | 04/12/2037 | Takanosu | JPN | Left | Right | 6' 2" | 210 lbs | - |
| Somers, Scott | 3B | Hatillo Lookouts | 31 | 08/03/2038 | s-Gravenhage | NED | Right | Right | 6' 1" | 200 lbs | - |
| Somolyano, Isiah | 2B | Hatillo Lookouts | 28 | 01/13/2042 | Loma Bonita | MEX | Right | Right | 6' 3" | 200 lbs | - |
| Song, Hyun-chul | SP | Santa Fe Crusaders | 26 | 02/22/2044 | Kuri | KOR | Right | Right | 6' 0" | 185 lbs | - |
| Sotero, Amauris | SP | Hatillo Lookouts | 30 | 02/26/2040 | San Cristzbal | DOM | Left | Right | 6' 6" | 220 lbs | - |
| Squires, Kevin | C | Cabano Black Aces | 33 | 03/16/2037 | Chilliwack | CAN | Right | Right | 6' 5" | 220 lbs | $1,100,000 |
| Sugahara, Tsuneari | 3B | Hatillo Lookouts | 27 | 12/18/2042 | Fukuoka | JPN | Right | Right | 6' 1" | 200 lbs | - |
