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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saikawa, Yoichi | SS | Cocorit Sawfish | 22 | 01/05/2048 | Osaka | JPN | Right | Right | 6' 1" | 185 lbs | - |
| Sampsal, Alberto | CF | La Descubierta Flamencos | 27 | 11/13/2042 | Villahermosa | MEX | Left | Left | 6' 1" | 200 lbs | - |
| Sandovel, Gustavo | LF | Cordoba Ants | 22 | 10/27/2047 | Vista Hermosa | PAN | Switch | Right | 6' 1" | 190 lbs | - |
| Santellana, Generoso | SS | Huaiyin Egrets | 24 | 01/20/2046 | La Barca | MEX | Right | Right | 6' 2" | 180 lbs | - |
| Sardaneta, Eduardo | SP | Gomez Palacio Cloudbursts | 23 | 02/25/2047 | Licey al Medio | DOM | Right | Right | 6' 1" | 200 lbs | - |
| Seki, Atsumori | SP | Cocorit Sawfish | 21 | 02/09/2049 | Toyama | JPN | Left | Right | 6' 2" | 195 lbs | - |
| Senda, Shohei | SP | Canoa Engines | 21 | 08/22/2048 | Atsugi | JPN | Right | Right | 6' 4" | 200 lbs | - |
| Sepúlveda, Juan | C | Canoa Engines | 24 | 04/10/2046 | Santiago | DOM | Switch | Right | 6' 1" | 200 lbs | - |
| Serenil, Juan | C | Cordoba Ants | 24 | 09/21/2045 | Moa | CUB | Left | Right | 6' 1" | 200 lbs | - |
| Serrano, Frank | SS | Nobleton Shamrocks | 20 | 08/30/2049 | Arecibo | PUR | Switch | Right | 6' 1" | 180 lbs | - |
| Si-ma, Xue-qin | RP | Suihua Golden Eagles | 24 | 06/19/2045 | Fuzhou | CHN | Switch | Right | 6' 3" | 200 lbs | - |
| Silva, Rosario | SS | Huaiyin Egrets | 21 | 05/03/2048 | San Cristzbal | DOM | Right | Right | 6' 2" | 195 lbs | - |
| Silvestre, Francisco | RP | Huaiyin Egrets | 21 | 03/18/2049 | Los Ríos | DOM | Right | Right | 6' 4" | 185 lbs | - |
| Simmon, Chris | SP | Gomez Palacio Cloudbursts | 24 | 07/16/2045 | Fayetteville | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sip, Sang-duk | C | Gomez Palacio Cloudbursts | 22 | 08/24/2047 | Seoul | KOR | Right | Right | 5' 10" | 195 lbs | - |
| Sixto, Júlio | 2B | Canoa Engines | 22 | 07/03/2047 | San Juan | PUR | Left | Right | 6' 3" | 180 lbs | - |
| So, Chin-yeol | RF | Huaiyin Egrets | 24 | 02/10/2046 | Chunchon | KOR | Left | Left | 6' 5" | 200 lbs | - |
| Soa, Orlando | SP | Huaiyin Egrets | 23 | 08/14/2046 | Havanna | CUB | Right | Right | 6' 3" | 200 lbs | - |
| Song, Jong-bum | RP | Nobleton Shamrocks | 25 | 06/01/2044 | Suwon | KOR | Switch | Right | 6' 0" | 195 lbs | - |
| Sugahara, Iwane | CF | La Descubierta Flamencos | 22 | 09/16/2047 | Tokyo | JPN | Right | Right | 6' 3" | 200 lbs | - |
| Sugano, Takahashi | RP | Cocorit Sawfish | 34 | 12/11/2035 | Toyohashi | JPN | Left | Left | 5' 10" | 200 lbs | - |
| Suro, José | RP | Cordoba Ants | 31 | 04/05/2039 | San Mateo | VEN | Left | Left | 6' 6" | 220 lbs | - |
